N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands.

Abstract

The structure activity relationship of N'-benzylidene-benzohydrazide (NBB) binding to tau and paired helical filament (PHF) proteins as well as amyloid-β₁₋₄₂ fibrils indicate differential selectivity for these protein aggregates. The ability of the compounds to stain neurofibrillary tangles and senile plaques isolated from human AD brain was investigated histochemically. These studies resulted in several tau-PHF and amyloid-β₁₋₄₂ fibril selective ligands respectively. Supported by these results, we rationalized a model for the design of selective ligands for tau, PHF, and amyloid-β₁₋₄₂ fibrils.

DOI: 10.3233/JAD-2011-111238

Cite this paper

@article{Taghavi2011NbenzylidenebenzohydrazidesAN, title={N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands.}, author={Ali Taghavi and Samir Nasir and Marcus Pickhardt and Roland Heyny-von Haussen and Gerhard Mall and E . - M . Mandelkow and Eva Maria Mandelkow and Boris Schmidt}, journal={Journal of Alzheimer's disease : JAD}, year={2011}, volume={27 4}, pages={835-43} }