N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits.

  title={N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits.},
  author={Kate Koles and Patrick H.C. van Berkel and Frank R. Pieper and Jan H. Nuijens and Maurice L M Mannesse and Johannes F. G. Vliegenthart and Johannis P. Kamerling},
  volume={14 1},
Human C1 inhibitor (hC1INH) is a therapeutic N, O-glycoprotein with a growing number of clinical applications, but the current natural supplies are not likely to meet the clinical demands. Therefore, recombinant approaches are of interest, whereby specific attention has to be paid to the generated glycosylation patterns. Here, the N,O-glycoprotein was expressed in the mammary gland of transgenic rabbits and subjected to glycan analysis. After release of the N-glycans of recombinant-rabbit human… CONTINUE READING
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