N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules.

@article{Cowley2000NAC,
  title={N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules.},
  author={Darrin J. Cowley and Yolonda Moore and Douglas S. Darling and Paul B. M. Joyce and Sven-Ulrik Gorr},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 11},
  pages={7743-8}
}
Chromogranins are a family of regulated secretory proteins that are stored in secretory granules in endocrine and neuroendocrine cells and released in response to extracellular stimulation (regulated secretion). A conserved N-terminal disulfide bond is necessary for sorting of chromogranins in neuroendocrine PC12 cells. Surprisingly, this disulfide bond is… CONTINUE READING