N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.

@article{Wright1982NaminoacylDO,
  title={N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.},
  author={J. J. Wright and J. A. Albarella and L. R. Krepski and D. Loebenberg},
  journal={The Journal of antibiotics},
  year={1982},
  volume={35 7},
  pages={
          911-4
        }
}
Amphotericin B continues to be the drug of choice for the treatment of deep-seated fungal infections despite the usual accompaniment of severe toxic side-reaction and there has been considerable interest in recent years in developing a safer drug within this class of antibiotic1 • `8). We wish to report the synthesis of N-aminoacyl derivatives of polyene esters which appear to represent a significant advance in this area9). They are more water-soluble and less toxic than the parent polyenes… Expand
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