N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.

@article{Wright1982NaminoacylDO,
  title={N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.},
  author={J. J. Wright and J. A. Albarella and L. R. Krepski and D. Loebenberg},
  journal={The Journal of antibiotics},
  year={1982},
  volume={35 7},
  pages={
          911-4
        }
}
Amphotericin B continues to be the drug of choice for the treatment of deep-seated fungal infections despite the usual accompaniment of severe toxic side-reaction and there has been considerable interest in recent years in developing a safer drug within this class of antibiotic1 • `8). We wish to report the synthesis of N-aminoacyl derivatives of polyene esters which appear to represent a significant advance in this area9). They are more water-soluble and less toxic than the parent polyenes… Expand
21 Citations
Synthesis and biological evaluation of amphotericin B derivatives.
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References

SHOWING 1-10 OF 15 REFERENCES
N-glycosyl derivatives of polyene macrolide antibiotics.
  • 27
Synthesis and biological properties of alkyl esters of polyene antibiotics.
  • 32
Water - soluble guanidine derivatives of polyene macrolides and the esters thereof
  • 1981
In vitro studies with polyene methyl esters. Idem, Paper #470 12 Evaluation of N-D-ornithyl AME as a systemic antifungal agent. Idem, Paper #471 13
  • In vitro studies with polyene methyl esters. Idem, Paper #470 12 Evaluation of N-D-ornithyl AME as a systemic antifungal agent. Idem, Paper #471 13
  • 1980
The synthesis of amides of polyene macrolide antibiotics.
  • 20
Methyl esters of trimethylammonium derivatives of polyene macrolide antibiotics.
  • 22
Methyl esters of trimethylammonium salts of polyene macrolide antibiotics
  • 1979
Antimicrob. Agents Chemother
  • Antimicrob. Agents Chemother
  • 1975
...
1
2
...