N-acylsulfonamide linker activation by Pd-catalyzed allylation.

@article{He2006NacylsulfonamideLA,
  title={N-acylsulfonamide linker activation by Pd-catalyzed allylation.},
  author={Yi He and Jesse P Wilkins and Laura L Kiessling},
  journal={Organic letters},
  year={2006},
  volume={8 12},
  pages={2483-5}
}
N-Acylsulfonamide safety-catch linkers are versatile tools in solid-phase organic synthesis because of their stability. This stability necessitates linker activation prior to compound cleavage. Here, we demonstrate that the N-acylsulfonamide group can react with a pi-allyl palladium complex and that these mild and neutral conditions can be exploited for… CONTINUE READING