N-acylsulfonamide linker activation by Pd-catalyzed allylation.

Abstract

N-Acylsulfonamide safety-catch linkers are versatile tools in solid-phase organic synthesis because of their stability. This stability necessitates linker activation prior to compound cleavage. Here, we demonstrate that the N-acylsulfonamide group can react with a pi-allyl palladium complex and that these mild and neutral conditions can be exploited for… (More)

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Cite this paper

@article{He2006NacylsulfonamideLA, title={N-acylsulfonamide linker activation by Pd-catalyzed allylation.}, author={Yi He and Jesse P Wilkins and Laura L Kiessling}, journal={Organic letters}, year={2006}, volume={8 12}, pages={2483-5} }