N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.

@article{Guo2005Nacylphosphatidylethanolaminehydrolyzi,
  title={N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.},
  author={Yong Guo and Haibin Wang and Yasuo Okamoto and Natsuo Ueda and Philip J. Kingsley and Lawrence J Marnett and Harald H. O. Schmid and Sanjoy Kumar Das and Sudhansu K Dey},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 25},
  pages={23429-32}
}
Implantation requires reciprocal interaction between blastocysts and a receptive uterus. In mice, one important player in this dialogue involves endocannabinoid signaling via cannabinoid receptor CB1. Anandamide is an endogenous cannabinoid ligand, and its levels are spatiotemporally regulated in the uterus during early pregnancy, showing lower levels in the receptive uterus and at the implantation site. However, the mechanism by which differential uterine anandamide gradients are established… CONTINUE READING

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