N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity.

@article{Alencar2014NacylhydrazoneDA,
  title={N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity.},
  author={Allan K. N. Alencar and S. L. Pereira and F. E. da Silva and L. V. Mendes and V. Cunha and L. M. Lima and T. Montagnoli and C. Caruso-Neves and E. B. Ferraz and R. Tesch and J. Nascimento and Carlos M R Sant'Anna and Carlos A M Fraga and E. Barreiro and R. T. Sudo and G. Zapata-Sudo},
  journal={International journal of cardiology},
  year={2014},
  volume={173 2},
  pages={
          154-62
        }
}
BACKGROUND Pulmonary arterial hypertension (PAH) is a disease that results in right ventricular (RV) dysfunction. While pulmonary vascular disease is the primary pathological focus, RV hypertrophy and RV dysfunction are the major determinants of prognosis in PAH. The aim of this study was to investigate the effects of (E)-N'-(3,4-dimethoxybenzylidene)-4-methoxybenzohydrazide (LASSBio-1386), an N-acylhydrazone derivative, on the lung vasculature and RV dysfunction induced by experimental PAH… Expand
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