N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila.

@article{Khajanchi2009NacylhomoserineLI,
  title={N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila.},
  author={Bijay K Khajanchi and Jian Sha and Elena V. Kozlova and Tatiana E. Erova and Giovanni Dell ’ Ariccia Luc Laeven Gustavo Suarez and Johanna Carolina Sierra and Vsevolod L. Popov and Amy J. Horneman and Ashok Kumar Chopra},
  journal={Microbiology},
  year={2009},
  volume={155 Pt 11},
  pages={3518-31}
}
In this study, we delineated the role of N-acylhomoserine lactone(s) (AHLs)-mediated quorum sensing (QS) in the virulence of diarrhoeal isolate SSU of Aeromonas hydrophila by generating a double knockout Delta ahyRI mutant. Protease production was substantially reduced in the Delta ahyRI mutant when compared with that in the wild-type (WT) strain. Importantly, based on Western blot analysis, the Delta ahyRI mutant was unable to secrete type VI secretion system (T6SS)-associated effectors… CONTINUE READING
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