N-acylation of phosphatidylethanolamine and its biological functions in mammals.

  title={N-acylation of phosphatidylethanolamine and its biological functions in mammals.},
  author={Niels Wellner and Thi Ai Diep and Christian Janfelt and Harald S Hansen},
  journal={Biochimica et biophysica acta},
  volume={1831 3},
N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain… CONTINUE READING
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