N-acylation of ethanolamine using lipase: a chemoselective catalyst

Abstract

The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym((R)) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and… (More)
DOI: 10.3762/bjoc.5.10

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