N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress

@article{Ashba2016NacylDI,
  title={N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress},
  author={A. M. Ashba and Mikhail G Akimov and Natalia M Gretskaya and Vladimir V. Bezuglov},
  journal={Doklady Biochemistry and Biophysics},
  year={2016},
  volume={467},
  pages={81-84}
}
It was shown that dopamine amides of arachidonic, oleic, and docosahexaenoic acids exhibit toxicity with respect to PC12 pheochromocytoma cell line. The mechanism of realization of the cytotoxic effect of acyl dopamines is the induction of oxidative stress. This event is preceded by triggering the synthesis of nitric oxide.