N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?

@article{JAG2000Nacetyltransferase2,
  title={N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?},
  author={Ag{\'u}ndez JAG and Luis Alberto Moncaleano Lozano and Jos{\'e} Mar{\'i}a Ladero and Javier Mart{\'i}nez Sastre and Francisca Cerd{\'a}n and Manuel D{\'i}az-Rubio and Julio Cesar Munoz Benitez},
  journal={Scandinavian journal of gastroenterology},
  year={2000},
  volume={35 10},
  pages={
          1087-91
        }
}
BACKGROUND Dietary heterocyclic aromatic amines (HAAs) are members of a family of chemicals that comprise highly mutagenic compounds related to colon cancer. The polymorphic N-acetyltransferase 2 enzyme (NAT2, E.C. 2.3.1.5) plays a key role in the transformation of HAAs to ultimate carcinogens. NAT2 enzyme activity is expressed in a genotype-dependent manner in colon epithelium. Therefore local activation of HAAs in colon, and hence increased risk to develop colon cancer, is likely to be… CONTINUE READING
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