N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis

@article{Ricart2002Nacetyltransferase1A,
  title={N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis},
  author={Elena Ricart and William R Taylor and Edward Vincent Loftus and D J O'kane and Richard M. Weinshilboum and William J. Tremaine and William Scott Harmsen and Alan R. Zinsmeister and W J Sandborn},
  journal={American Journal of Gastroenterology},
  year={2002},
  volume={97},
  pages={1763-1768}
}
OBJECTIVES:5-Aminosalicylate is metabolized in colonic mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2). Common genetic polymorphisms in these enzymes result in rapid and slow acetylation. We determined the association between NAT1 genotype and response to mesalamine and sulfasalazine, as well as between NAT2 genotype and toxicity to sulfasalazine, in a population-based cohort of patients with ulcerative colitis.METHODS:DNA… CONTINUE READING
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Evolution of serologic disease markers in a population cohort of patients with ulcerative colitis and Crohn’s disease

  • WJ Sandborn, Loftus EV, Colombel J-F
  • Inflamm Bowel Dis 2002;7:192–201
  • 2002
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