N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing.

@article{Uchimura2004Nacetylglucosamine6R,
  title={N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing.},
  author={Kenji Uchimura and Kenji Kadomatsu and Fathy M. Elfasakhany and Mark S. Singer and Mineko Izawa and Reiji Kannagi and Naoki Takeda and S D Rosen and Takashi Muramatsu},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 33},
  pages={
          35001-8
        }
}
  • Kenji Uchimura, Kenji Kadomatsu, +6 authors Takashi Muramatsu
  • Published in
    The Journal of biological…
    2004
  • Biology, Medicine
  • Lymphocyte homing is initiated by the binding of L-selectin on lymphocytes to its ligands on high endothelial venules (HEV). Sialyl 6-sulfo Lewis X is a major capping group of L-selectin ligands. N-Acetylglucosamine (GlcNAc) 6-sulfation is essential for the ligand activity, and is catalyzed by GlcNAc 6-O-sulfotransferases (GlcNAc6STs) of which GlcNAc6ST-1 and GlcNAc6ST-2 are expressed in HEV. Here, we report that mice deficient in GlcNAc6ST-1 were impaired in the elaboration of sialyl 6-sulfo… CONTINUE READING

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