N-acetylcysteine treatment reduces TNF-α levels and myonecrosis in diaphragm muscle of mdx mice.

@article{Pinto2013NacetylcysteineTR,
  title={N-acetylcysteine treatment reduces TNF-α levels and myonecrosis in diaphragm muscle of mdx mice.},
  author={Rafael de Senzi Moraes Pinto and Renato Ferretti and Luis Henrique Rapucci Moraes and Humberto Santo Neto and Maria J{\'u}lia Marques and Elaine Minatel},
  journal={Clinical nutrition},
  year={2013},
  volume={32 3},
  pages={472-5}
}
BACKGROUND & AIMS Duchenne muscular dystrophy (DMD) is a genetic muscle disease caused by the absence of dystrophin. An established animal model of DMD is the mdx mouse, which is unable to express dystrophin. Inflammation, particularly the proinflammatory cytokine tumor necrosis factor alpha (TNF-α), strongly contributes to necrosis in the dystrophin-deficient fibers of the mdx mice and in DMD. In this study we investigated whether the antioxidant N-acetylcysteine (NAC) decreases TNF-α levels… CONTINUE READING