N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases.

@article{Oka2000NacetylcysteineST,
  title={N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases.},
  author={Shin-ichi Oka and Hideaki Kamata and Keiko Kamata and Hitoshi Yagisawa and Hajime Hirata},
  journal={FEBS letters},
  year={2000},
  volume={472 2-3},
  pages={196-202}
}
Here, we used a reductant, N-acetyl-L-cysteine (NAC), to investigate the redox-sensitive step(s) in the signalling pathway from the tumor necrosis factor (TNF) receptor to nuclear factor kappaB (NF-kappaB). We found that NAC suppressed NF-kappaB activation triggered by TNF or by overexpression of either the TNF receptor-associated death domain protein, TNF receptor-associated factor 2, NF-kappaB-inducing kinase (NIK), or IkappaB kinases (IKKalpha and IKKbeta). NAC also suppressed the TNF… CONTINUE READING