N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet.

@article{Cao2014NacetylcysteineSD,
  title={N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet.},
  author={Jay J. Cao and Matthew J. Picklo},
  journal={The Journal of nutrition},
  year={2014},
  volume={144 3},
  pages={289-96}
}
Obesity induced by high-fat (HF) diets increases bone resorption, decreases trabecular bone mass, and reduces bone strength in various animal models. This study investigated whether N-acetylcysteine (NAC), an antioxidant and a glutathione precursor, alters glutathione status and mitigates bone microstructure deterioration in mice fed an HF diet. Forty-eight… CONTINUE READING