N-acetylcysteine replenishes glutathione in HIV infection.

@article{Rosa2000NacetylcysteineRG,
  title={N-acetylcysteine replenishes glutathione in HIV infection.},
  author={Stephen C. De Rosa and Malcolm D. Zaretsky and J G Dubs and Mario Roederer and Michael G. Anderson and Alex A. Green and Debi L Mitra and Norihito Watanabe and Hayato Nakamura and I M Tjioe and Stanley C. Deresinski and Walter Moore and Steve Ela and D Parks and Leonard A. Herzenberg},
  journal={European journal of clinical investigation},
  year={2000},
  volume={30 10},
  pages={915-29}
}
BACKGROUND Glutathione (GSH) deficiency is common in HIV-infected individuals and is associated with impaired T cell function and impaired survival. N-acetylcysteine (NAC) is used to replenish GSH that has been depleted by acetaminophen overdose. Studies here test oral administration of NAC for safe and effective GSH replenishment in HIV infection. DESIGN Oral NAC administration in a randomized, 8-week double-blind, placebo-controlled trial followed by optional open-label drug for up to 24… CONTINUE READING
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