N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients.


OBJECTIVE The antioxidant N-acetylcysteine (NAC) has been shown to attenuate septic tissue injury. To evaluate whether NAC affects host defense mechanisms in critically ill patients, thus predisposing to increased risk of infection, the current study focuses on neutrophil phagocytotic and burst activity after treatment with NAC. DESIGN Prospective… (More)


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