N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain.

@article{Paintlia2004NacetylcysteinePE,
  title={N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain.},
  author={Manjeet Kaur Paintlia and Ajaib Singh Paintlia and Ernest Barbosa and Inderjit Singh and Avtar Kaur Singh},
  journal={Journal of neuroscience research},
  year={2004},
  volume={78 3},
  pages={
          347-61
        }
}
Periventricular leukomalacia (PVL), the dominant form of brain injury in premature infants, is characterized by diffuse white matter injury and is associated with cerebral palsy (CP). Maternal and placental infections are major causes of prematurity and identifiable etiology of PVL and CP. Here we have evaluated the therapeutic efficacy of N-acetylcysteine (NAC), a potent antioxidant and precursor of glutathione, to attenuate lipopolysaccharide (LPS)-induced white matter injury and… CONTINUE READING
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