N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction

@article{Visalli2007NacetylcysteinePH,
  title={N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction},
  author={Valeria Visalli and Carolina Muscoli and Iolanda Sacco and Francesca Sculco and Ernesto Palma and N. S. Santos Costa and Carmela Colica and Domenicoantonio Rotiroti and Vincenzo Mollace},
  journal={BMC Neuroscience},
  year={2007},
  volume={8},
  pages={106 - 106}
}
HIV envelope gp 120 glycoprotein is released during active HIV infection of brain macrophages thereby generating inflammation and oxidative stress which contribute to the development of the AIDS-Dementia Complex (ADC). Gp120 has also been found capable to generate excitotoxic effect on brain tissue via enhancement of glutamatergic neurotransmission, leading to neuronal and astroglial damage, though the mechanism is still to be better understood. Here we investigated on the effect of N… CONTINUE READING
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