N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains.

Abstract

Diclofenac (DCF) adverse reactions involve diverse mechanisms in different models. We recently demonstrated that DCF-induced toxicity in HepaRG decreases as they express DCF-metabolizing enzymes. DCF metabolism promotes toxicity in Saccharomyces cerevisiae expressing heterologous cytochromes-P450. N-Acetylcysteine (NAC) is used to treat diverse medical… (More)
DOI: 10.1080/01480545.2017.1320404

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Cite this paper

@article{AlAttrache2018NacetylcysteinePD, title={N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains.}, author={Houssein Al-Attrache and Hala Chamieh and Monzer Hamz{\'e} and Isabelle Morel and Samir Taha and Ziad Abdel-Razzak}, journal={Drug and chemical toxicology}, year={2018}, volume={41 1}, pages={89-94} }