N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial

@inproceedings{Fraga2016NacetylcysteinePD,
  title={N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial},
  author={Cassiana Mazon Fraga and Cristiane Damiani Tomasi and Danusa de Castro Damasio and Francieli Vuolo and Cristiane Ritter and Felipe Dal-Pizzol},
  booktitle={Critical Care},
  year={2016}
}
BackgroundThe aim was to test the primary hypothesis that in patients suffering from shock, treatment with N-acetylcysteine (NAC) plus deferoxamine (DFX) decreases the incidence of acute kidney injury (AKI).MethodsA double-blind, randomized, placebo-controlled trial was conducted in a general intensive care unit in an academic hospital. Patients were included if they had new-onset hypotension, defined as mean arterial blood pressure <60 mmHg or requirement for vasopressor medication. A loading… CONTINUE READING
6
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

NGAL-Siderocalin in kidney disease.

  • Biochimica et biophysica acta
  • 2012
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

The assessment of serum non-transferrin bound iron (NTBI) in chelation therapy and iron supplementation

W Breuer, A Ronson, +3 authors ZI. Cabantchik
  • Blood
  • 2016
VIEW 2 EXCERPTS

Molecular phenotyping of clinical AKI with novel urinary biomarkers.

  • American journal of physiology. Renal physiology
  • 2015
VIEW 1 EXCERPT

A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury

H Gomez, C Ince, +4 authors JA. Kellum
  • Shock
  • 2014

Hemolysis-induced lethality involves inflammasome activation by heme.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014
VIEW 1 EXCERPT