N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically.

@article{Caro2014NacetylcysteineIT,
  title={N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically.},
  author={Andr{\'e}s Caro and Matthew B. V. Bell and Shannon Ejiofor and Grant Zurcher and Dennis R. Petersen and Martin J. J. Ronis},
  journal={Alcoholism, clinical and experimental research},
  year={2014},
  volume={38 12},
  pages={2896-906}
}
BACKGROUND Chronic ethanol (EtOH) administration to experimental animals induces hepatic oxidative stress and up-regulates mitochondrial biogenesis. The mechanisms by which chronic EtOH up-regulates mitochondrial biogenesis have not been fully explored. In this work, we hypothesized that oxidative stress is a factor that triggers mitochondrial biogenesis after chronic EtOH feeding. If our hypothesis is correct, co-administration of antioxidants should prevent up-regulation of mitochondrial… CONTINUE READING
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