N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy.

@article{Kamboj2010NacetylcysteineIH,
  title={N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy.},
  author={Sukhdev Singh Kamboj and Rakesh kumar Vasishta and Rajat Sandhir},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 1},
  pages={77-91}
}
Several studies have indicated the involvement of oxidative stress in the development of diabetic neuropathy. In the present study, we have targeted oxidative stress mediated nerve damage in diabetic neuropathy using N-acetyl-l-cysteine (NAC), a potent antioxidant. After 8 weeks, streptozotocin-induced diabetic rats developed neuropathy which was evident from decreased tail-flick latency (thermal hyperalgesia). This was accompanied by decreased motor coordination as assessed by performance on… CONTINUE READING

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