N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition.

  title={N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition.},
  author={Valerie M Felton and Zea Borok and B Cicero Willis},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={297 5},
The ability of transforming growth factor-beta1 (TGF-beta1) to induce epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AEC) in vitro and in vivo, together with the demonstration of EMT in biopsies of idiopathic pulmonary fibrosis (IPF) patients, suggests a role for TGF-beta1-induced EMT in disease pathogenesis. We investigated the effects of N-acetylcysteine (NAC) on TGF-beta1-induced EMT in a rat epithelial cell line (RLE-6TN) and in primary rat alveolar epithelial cells… CONTINUE READING
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