N-acetylcysteine improves renal hemodynamics in rats with cisplatin-induced nephrotoxicity.

@article{Abdelrahman2010NacetylcysteineIR,
  title={N-acetylcysteine improves renal hemodynamics in rats with cisplatin-induced nephrotoxicity.},
  author={Aly M Abdelrahman and Suhail Al Salam and Ahmed S AlMahruqi and Ishaq S Al husseni and Mohamed A Mansour and Badreldin H Ali},
  journal={Journal of applied toxicology : JAT},
  year={2010},
  volume={30 1},
  pages={15-21}
}
This work investigated the effect of N-acetylcysteine (NAC), on renal hemodynamics in cisplatin (CP)-induced nephrotoxicity in Wistar-Kyoto (WKY) rats. The animals were divided into four groups (n = 5 or 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) N-acetylcysteine (500 mg kg(-1) per day for 9 days), respectively. The third and fourth groups were given a single intraperitoneal (i.p.) injection of CP (5 mg kg(-1)) and an i.p. injection of CP (5 mg… CONTINUE READING
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