N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance.

@article{Akan2004NacetylcysteineEM,
  title={N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance.},
  author={Ilhan Akan and Selma Yenisoy Akan and Hakan Akça and Burhan Savaş and Tomris Ozben},
  journal={European journal of clinical investigation},
  year={2004},
  volume={34 10},
  pages={683-9}
}
BACKGROUND Resistance of cancer cells against anticancer agents is caused partly by multidrug resistance-associated protein 1 (MRP1). The exact mechanism of MRP1-involved multidrug resistance has not yet been clarified, although glutathione (GSH) is likely to have a role for the resistance to occur. N-acetylcysteine (NAC) is a pro-glutathione drug. DL-buthionine (S,R)-sulfoximine (BSO) inhibits GSH synthesis. The aim of our study was to investigate the effect of NAC and BSO on MRP1-mediated… CONTINUE READING
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