N-acetylcysteine attenuates the progression of chronic renal failure.

  title={N-acetylcysteine attenuates the progression of chronic renal failure.},
  author={Maria Helo{\'i}sa Massola Shimizu and Terezila Machado Coimbra and Magali de Araujo and Luis F Menezes and Ant{\^o}nio Carlos Seguro},
  journal={Kidney international},
  volume={68 5},
BACKGROUND Lipid peroxidation impairs renal function. Aldosterone contributes to renal injury in the remnant kidney model. This study aimed to determine the effects of the antioxidant N-acetylcysteine (NAC) on renal function and aldosterone levels in chronic renal failure. METHODS Adult male Wistar rats were submitted to 5/6 nephrectomy or laparotomy (sham-operated) and received NAC (600 mg/L in drinking water, initiated on postoperative day 7 or 60), spironolactone (1.5 g/kg of diet… CONTINUE READING