N-acetylcysteine attenuates renal alterations induced by senescence in the rat.

  title={N-acetylcysteine attenuates renal alterations induced by senescence in the rat.},
  author={Maria Helo{\'i}sa Massola Shimizu and Rildo Aparecido Volpini and Ana Carolina de Bragança and Renata Jacob Daniel Salom{\~a}o Campos and Daniele Canale and Talita Rojas Cunha Sanches and Lucia Helena Raymundo Andrade and Ant{\^o}nio Carlos Seguro},
  journal={Experimental gerontology},
  volume={48 2},
The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) on renal function, as well as on sodium and water transporters, in the kidneys of aged rats. Normal, 8-month-old male Wistar rats were treated (n=6) or not (n=6) with NAC (600 mg/L in drinking water) and followed for 16 months. At the end of the follow-up period, we determined inulin clearance, serum thiobarbituric acid reactive substances (TBARS), serum cholesterol, and urinary phosphate excretion. In addition, we… CONTINUE READING