N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression.

@article{Ji2010NacetylcysteineAP,
  title={N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression.},
  author={Lin Ji and Rui Liu and Xiao Zhang and Hong Li Chen and Hua Bai and Xin Wang and Hai Zhao and Xin Liang and Chun Xu Hai},
  journal={Inhalation toxicology},
  year={2010},
  volume={22 7},
  pages={535-42}
}
Previous studies indicated that oxidative stress was involved in phosgene-induced acute lung injury (ALI) and many antioxidants had been used to prevent ALI. N-acetylcysteine (NAC) had been used to protect ALI induced by various types of oxidative stress. Considering the limited information of NAC on phosgene-induced ALI, the purpose of this study was to elucidate the molecular mechanisms of phosgene-induced ALI and the protective effects of NAC. This study discovered that intraperitoneal… CONTINUE READING
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