N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

@article{Okamura2016NacetylcysteineAN,
  title={N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats},
  author={Adriana Mary Nunes Costa Okamura and Patr{\'i}cia Xavier Lima Gomes and Gersilene Valente de Oliveira and Fernanda Yvelize Ramos de Ara{\'u}jo and Danielle Mac{\^e}do},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2016},
  volume={67},
  pages={58-65}
}
Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC… CONTINUE READING
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