N-acetylcysteine attenuates cardiopulmonary bypass-induced lung injury in dogs

  title={N-acetylcysteine attenuates cardiopulmonary bypass-induced lung injury in dogs},
  author={Xianfeng Qu and Qianyu Li and Xiaofei Wang and Xiaoping Yang and Dongguo Wang},
  booktitle={Journal of cardiothoracic surgery},
BACKGROUND Cardiopulmonary bypass (CPB) is usually associated with inflammatory response that leads to various degrees of organ dysfunction in multiple systems, including lung injury. Our previous study showed that transforming growth factor beta1 (TGFβ1) was involved in CPB-induced lung injury. N-acetylcysteine (NAC) is an antioxidant and is able to prevent CPB-induced pneumocyte apoptosis through scavenging radical. Therefore, we investigated whether NAC may attenuate CPB-induced lung injury… CONTINUE READING
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