N-acetylcysteine and sodium bicarbonate versus N-acetylcysteine and standard hydration for the prevention of radiocontrast-induced nephropathy following coronary angiography.

@article{Schmidt2007NacetylcysteineAS,
  title={N-acetylcysteine and sodium bicarbonate versus N-acetylcysteine and standard hydration for the prevention of radiocontrast-induced nephropathy following coronary angiography.},
  author={Paul J Schmidt and Dorothy Pang and Diane L Nykamp and Gregory Knowlton and Haomiao Jia},
  journal={The Annals of pharmacotherapy},
  year={2007},
  volume={41 1},
  pages={46-50}
}
BACKGROUND Radiocontrast-induced nephropathy (RCIN) is thought to be caused by renal ischemia and direct toxic effects on renal tubular cells brought on by contrast media. The combination of N-acetylcysteine (NAC) and hydration fluids (NaCl 0.9% or 0.45%) has been shown to reduce these deleterious effects and is commonly given prior to coronary angiography. The use of bicarbonate as the hydration anion has been shown to confer additional RCIN protection compared with that of saline. However… CONTINUE READING

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