N-acetylcysteine and alpha-tocopherol reverse the inflammatory response in activated rat Kupffer cells.

@article{Fox1997NacetylcysteineAA,
  title={N-acetylcysteine and alpha-tocopherol reverse the inflammatory response in activated rat Kupffer cells.},
  author={Erika Schwenn Fox and Jason S. Brower and Joseph M Bellezzo and K A Leingang},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5418-23}
}
Activation of the resident macrophage populations of the reticuloendothelial system is a key component of the complex pathophysiology of sepsis. Macrophage activation leads to production and secretion of inflammatory mediators such as cytokines, vasoactive substances, free radicals, and chemokines, which have been associated with high morbidity and mortality in the septic patient. The goal of the present study was to determine whether antioxidants could suppress Kupffer cell activation at… CONTINUE READING