N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury

@article{Zhou2018NacetylcysteineAP,
  title={N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury},
  author={Yuan Zhou and Han-dong Wang and Xiao-ming Zhou and Jiang Fang and Lin Zhu and Ke Ding},
  journal={Drug Design, Development and Therapy},
  year={2018},
  volume={12},
  pages={4117 - 4127}
}
Background Increasing evidence demonstrate N-acetylcysteine amide (NACA) provides neuroprotection and attenuated oxidative stress in rats following traumatic brain injury (TBI). The nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) signal pathway is activated after TBI and provides a protective effect against TBI. However, the function and mechanism of NACA in mice after TBI remain unknown. This study was to evaluate the neuroprotection of NACA and the… Expand
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