Corpus ID: 29039543

N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.

@article{etinkaya2006NacetylcysteineAM,
  title={N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.},
  author={Ali Osman Çetinkaya and Ertan Bulbuloglu and Erg{\"u}l Belge Kurutaş and Bulent Kantarçeken},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2006},
  volume={12 8},
  pages={
          BR274-8
        }
}
BACKGROUND Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent for malignancies as well as in the treatment of various inflammatory diseases. The efficacy of this agent is often limited by severe side effects and toxic conditions. The present study was undertaken to determine whether N-acetylcysteine (NAC), as a potent antioxidant compound, could ameliorate MTX-induced oxidative liver damage. MATERIAL/METHODS A single dose of MTX (20 mg/kg… Expand
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