Corpus ID: 29039543

N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.

  title={N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.},
  author={Ali Osman Çetinkaya and Ertan Bulbuloglu and Erg{\"u}l Belge Kurutaş and Bulent Kantarçeken},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  volume={12 8},
BACKGROUND Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent for malignancies as well as in the treatment of various inflammatory diseases. The efficacy of this agent is often limited by severe side effects and toxic conditions. The present study was undertaken to determine whether N-acetylcysteine (NAC), as a potent antioxidant compound, could ameliorate MTX-induced oxidative liver damage. MATERIAL/METHODS A single dose of MTX (20 mg/kg… Expand
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats.
By increasing antioxidant defense in hepatic tissues and reducing oxidative stress and proinflammatory mediators, pretreatment with CRO could alleviate MTX-induced hepatotoxicity. Expand
Antioxidant and hepatoprotective property of squalene for counteracting the oxidative damage induced by methotrex- ate in experimental rats
Methotrexate (MTX), an antifolate drug, is extensively prescribed for patients suffering from diseases like cancer, psoriasis, neoplasms, and rheumatoid arthritis. Despite its effectiveness, MTXExpand
Effects of Misoprostol on Methotrexate-Induced Hepatic and Renal Damages
It is indicated that PGE1 analogue misoprostol (MP) has beneficial effects on MTX induced nephrotoxicity and hepatotoxicity in rats. Expand
Effects of methotrexate on antioxidant enzyme status in a rodent model
The results indicate that methotrexate causes oxidative stress by reducing the activities and consequently the effectiveness of the antioxidant enzyme defense system. Expand
Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach.
Findings demonstrated the hepatoprotective nature of CGA by attenuating the pro-inflammatory and apoptotic mediators and improving antioxidant competence in hepatic tissue and imply that CGA has perfective effect against MTX-induced liver injury. Expand
Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats.
From the results of this study, it is observed that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX. Expand
Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats
It is concluded that Co-treatment with GLE has beneficial properties and can reduce the liver and kidney damages and toxicity induced by MTX. Expand
Protective effects of erythropoietin and N-acetylcysteine on methotrexate-induced lung injury in rats.
EPO and NAC have significant preventive effects on MTX-induced lung injury in rats and decreased antioxidant capacity and increased MDA level may cause the oxidative damage in MTX group. Expand
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
Administration of curcumin once daily for 5 consecutive days after MTX challenge mitigated the injurious effects of MTX and ameliorated all the altered biochemical parameters, indicating thatCurcumin may be of therapeutic benefit against MTX-cytotoxicity. Expand
Protective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Rats
Results indicate that BCA may be useful in preventing the MTX-induced acute liver injury due to its antioxidant and anti-inflammatory properties. Expand