N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy.

@article{Ware2013NacetylcysteineAA,
  title={N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy.},
  author={Kyle M. Ware and Zahida Qamri and Ayhan Ozcan and Anjali A. Satoskar and Gyongyi M Nadasdy and Brad H. Rovin and Lee A. Hebert and Tibor Nadasdy and Sergey V Brodsky},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={304 12},
  pages={F1421-7}
}
Warfarin-related nephropathy (WRN) occurs under conditions of overanticoagulation with warfarin. WRN is characterized by glomerular hemorrhage with occlusive tubular red blood cell (RBC) casts and acute kidney injury (AKI). Herein we test the hypothesis that oxidative stress plays a role in the AKI of WRN. 5/6 Nephrectomy rats were treated with either warfarin (0.04 mg·kg⁻¹·day⁻¹) alone or with four different doses of the antioxidant N-acetylcysteine (NAC). Also tested was the ability of our… CONTINUE READING

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