N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

@article{Klauser2018NacetylcysteineAT,
  title={N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial},
  author={Paul Klauser and Lijing Xin and Margot Fournier and Alessandra Griffa and Martine Cleusix and Raoul Jenni and M. Cu{\'e}nod and Rolf Gruetter and Patric Hagmann and Philippe Conus and Philipp S. Baumann and Kim Q. Do},
  journal={Translational Psychiatry},
  year={2018},
  volume={8}
}
  • Paul Klauser, Lijing Xin, +9 authors Kim Q. Do
  • Published 2018
  • Psychology, Medicine
  • Translational Psychiatry
  • Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side effects, improved negative symptoms, decreased the side effects of antipsychotics, and improved mismatch negativity and local neural synchronization in chronic schizophrenia. In a recent double-blind randomized placebo-controlled trial by Conus… CONTINUE READING

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