N-acetylcysteine abrogates acute lung injury induced by endotoxin.

  title={N-acetylcysteine abrogates acute lung injury induced by endotoxin.},
  author={Shang Jyh Kao and David Daoyi Wang and Hen I Lin and Hsing I. Chen},
  journal={Clinical and experimental pharmacology & physiology},
  volume={33 1-2},
1. Acute lung injury (ALI) or acute respiratory distress syndrome is a serious clinical problem with high mortality. N-Acetylcysteine (NAC) is an anti-oxidant and a free radical scavenger. It has been reported recently that NAC ameliorates organ damage induced by endotoxin (lipopolysaccharide; LPS) in conscious rats. The present study was designed to evaluate the effects of NAC on LPS-induced ALI and other changes in anaesthetized rats. 2. Sprague-Dawley rats were anaesthetized with… CONTINUE READING
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