N-acetylcysteine: a new approach to anti-HIV therapy.

  title={N-acetylcysteine: a new approach to anti-HIV therapy.},
  author={Mario Roederer and Steve Ela and Frank J. T. Staal and Leonard A. Herzenberg},
  journal={AIDS research and human retroviruses},
  volume={8 2},
Several investigators have implicated depletion of glutathione (GSH) and production of reactive oxygen intermediates (ROIs) in the regulation of the human immunodeficiency virus (HIV). We have shown directly that N-acetylcysteine (NAC) blocks HIV expression in chronic and acute infection models, and HIV replication in normal peripheral blood mononuclear cells. NAC is a cysteine prodrug which maintains intracellular thiol levels during oxidative stress and replenishes depleted GSH. The observed… CONTINUE READING


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