N-acetylation and phosphorylation of Sec complex subunits in the ER membrane

Abstract

Covalent modifications of proteins provide a mechanism to control protein function. Here, we have investigated modifications of the heptameric Sec complex which is responsible for post-translational protein import into the endoplasmic reticulum (ER). It consists of the Sec61 complex (Sec61p, Sbh1p, Sss1p) which on its own mediates cotranslational protein… (More)
DOI: 10.1186/1471-2121-13-34

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