N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.

@article{Burlina1994NacetylaspartylglutamateSI,
  title={N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.},
  author={A Burlina and Stephen D Skaper and M{\'a}rcia Maria Porto Roccetto Mazza and Vera Ferrari and Albertine Leon and Alberto B. Burlina},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 3},
  pages={1174-7}
}
Canavan's disease is an autosomal recessive disorder characterized by a deficiency of aspartoacylase and accumulation of N-acetylaspartic acid (NAA), leading to a severe leukodystrophy and spongy degeneration of the brain. N-Acetylaspartylglutamate (NAAG), the presumed product of NAA, also accumulates in this disease. The endogenous dipeptide NAAG has been suggested to have low potency at NMDA receptors. Here we have tested the actions of NAAG and NAA on NMDA-evoked responses in cultured… CONTINUE READING