N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents

@inproceedings{Mazzoccoli2016NacetylaspartateI,
  title={N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents},
  author={Carmela Mazzoccoli and Vitalba Ruggieri and Tiziana Tataranni and Francesca Agriesti and Ilaria Laurenzana and Angelo Fratello and Nazzareno Capitanio and Claudia Piccoli},
  booktitle={Oncotarget},
  year={2016}
}
Neuroblastoma is the most commonly extra-cranial solid tumor of childhood frequently diagnosed. The nervous system-specific metabolite N-acetylaspartate (NAA) is synthesized from aspartate and acetyl-CoA in neurons, it is among the most abundant metabolites present in the central nervous system (CNS) and appears to be involved in many CNS disorders. The functional significance of the high NAA concentration in the brain remains uncertain, but it confers to NAA a unique clinical significance… CONTINUE READING
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