N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.

@article{Long2013NacetylaspartateA,
  title={N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.},
  author={Patrick M. Long and John R. Moffett and Aryan M. A. Namboodiri and Mariano Sebastian Viapiano and Sean E Lawler and Diane M. Jaworski},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 36},
  pages={26188-200}
}
Metabolic reprogramming is a pathological feature of cancer and a driver of tumor cell transformation. N-Acetylaspartate (NAA) is one of the most abundant amino acid derivatives in the brain and serves as a source of metabolic acetate for oligodendrocyte myelination and protein/histone acetylation or a precursor for the synthesis of the neurotransmitter N-acetylaspartylglutamate (NAAG). NAA and NAAG as well as aspartoacylase (ASPA), the enzyme responsible for NAA degradation, are significantly… CONTINUE READING
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Characterization of the MAL2-positive compartment in oligodendrocytes

  • R. Bello-Morales, M. C. de Marco, J. F. Aranda, F. Matesanz, A. Alcina, J. A. López-Guerrero
  • Exp. Cell Res
  • 2009
Highly Influential
3 Excerpts

NAA and NAAG Inhibit Glioma Stem-like Cell Differentiation 26198 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • C. Liu, J. C. Sage, +8 authors H. Zong
  • Cell 146,
  • 2013
1 Excerpt

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