N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis.

@article{Sirianni2015NacetylltryptophanBN,
  title={N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis.},
  author={Ana C. Sirianni and Jiying Jiang and Jiang Zeng and Lilly L J Mao and Shuanhu Zhou and Peter E. Sugarbaker and Xinmu Zhang and Wei Li and Robert Max Friedlander and Xin Wang},
  journal={Journal of neurochemistry},
  year={2015},
  volume={134 5},
  pages={956-68}
}
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss. Evidence suggests that mitochondrial dysfunction, apoptosis, oxidative stress, inflammation, glutamate excitotoxicity, and proteasomal dysfunction are all responsible for ALS pathogenesis. N-acetyl-tryptophan has been identified as an inhibitor of mitochondrial cytochrome c release and therefore is a potential neuroprotective agent. By quantifying cell death, we demonstrate that N… CONTINUE READING