N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

@article{Dean2011NacetylCR,
  title={N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder},
  author={O. Dean and M. Buuse and M. Berk and D. Copolov and A. Bush},
  journal={Neuroscience Letters},
  year={2011},
  volume={499},
  pages={149-153}
}
  • O. Dean, M. Buuse, +2 authors A. Bush
  • Published 2011
  • Biology, Medicine
  • Neuroscience Letters
  • Oxidative stress and reduced brain levels of glutathione have been implicated in schizophrenia and bipolar disorder. N-acetyl cysteine (NAC) is a precursor of glutathione and has additional effects on glutamate neurotransmission, neurogenesis and inflammation. While NAC treatment has shown benefits in both schizophrenia and bipolar disorder, the mechanisms of action are largely unknown. Similarly, the interaction between oxidative stress and altered dopaminergic activities in psychiatric… CONTINUE READING
    Antioxidants as potential therapeutics for neuropsychiatric disorders
    • 134
    Oxidative Stress and Psychological Disorders
    • 152
    • PDF
    Putative neuroprotective agents in neuropsychiatric disorders
    • 82
    • PDF
    Antioxidants as Antidepressants
    • 78

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 53 REFERENCES
    Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse
    • 394