N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

@article{Dean2011NacetylCR,
  title={N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder},
  author={Olivia M. Dean and Maarten van den Buuse and Michael Berk and David L. Copolov and Christine Mavros and Ashley I. Bush},
  journal={Neuroscience Letters},
  year={2011},
  volume={499},
  pages={149-153}
}

Figures from this paper

Neuroprotective Role of N-acetylcysteine against Learning Deficits and Altered Brain Neurotransmitters in Rat Pups Subjected to Prenatal Stress

It is suggested that NAC protect the progeny from an undesirable cognitive sequel associated with prenatal stress, and reversed learning and memory deficits as well as brain dopamine content in offspring.

Sex influences in the preventive effects of N-acetylcysteine in a two-hit animal model of schizophrenia

NAC prevented sensorimotor gating deficits only in females, while it prevented alterations in social interaction, working memory and locomotor activity in both sexes, highlights the influences of sex in NAC preventive effects in rats exposed to a two-hit schizophrenia model.

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

Current evidence supports N-acetylcysteine use as an adjunctive therapy clinically for psychiatric conditions, administered concomitantly with existing medications, with a recommended dosage between 2000 and 2400 mg/day.

Amphetamine Induces Oxidative Stress, Glial Activation and Transient Angiogenesis in Prefrontal Cortex via AT1-R

The results support the protective role of AT1-R blockade in AMPH-induced oxidative stress, transient angiogenesis and long-lasting glial activation, preserving working memory performance.

N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish

Improvement of cognitive function in schizophrenia with N-acetylcysteine: A theoretical review

Improved cognition in schizophrenia may result from a combination of factors, including decreased oxidative stress, neuroprotection of cognitive networks and an increase in glutamatergic modulation of the N-methyl-d-aspartate receptor system.
...

Effect of Chronic N-Acetyl Cysteine Administration on Oxidative Status in the Presence and Absence of Induced Oxidative Stress in Rat Striatum

N-acetylcysteine may protect against conditions of striatal oxidative stress, although possible pro-oxidative actions at high doses in otherwise healthy individuals, e.g. to offset worsening of neurodegenerative illness, should be viewed with caution.

Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d‐amphetamine administration

The modifications observed for the measured antioxidant enzymes reveal that oxidative stress probably plays a role in the deleterious effects of this drug in CNS and that, in general, the brain areas studied underwent adaptations which provided protection against the continuous administration of the drug.

Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

The findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum, in a rodent model of mania.

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders.

The finding that GSH levels are reduced in post-mortem prefrontal cortex suggests that these patient groups may be more susceptible to oxidative stress.

Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients

It is suggested that MMN enhancement may precede changes to indices of clinical severity, highlighting the possible utility AEPs as a biomarker of treatment efficacy, and the improvement of this functional marker may indicate an important pathway towards new therapeutic strategies that target glutathione dysregulation in schizophrenia.
...