N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

@article{Dean2011NacetylCR,
  title={N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder},
  author={O. Dean and M. Buuse and M. Berk and D. Copolov and A. Bush},
  journal={Neuroscience Letters},
  year={2011},
  volume={499},
  pages={149-153}
}
  • O. Dean, M. Buuse, +2 authors A. Bush
  • Published 2011
  • Chemistry, Medicine
  • Neuroscience Letters
  • Oxidative stress and reduced brain levels of glutathione have been implicated in schizophrenia and bipolar disorder. N-acetyl cysteine (NAC) is a precursor of glutathione and has additional effects on glutamate neurotransmission, neurogenesis and inflammation. While NAC treatment has shown benefits in both schizophrenia and bipolar disorder, the mechanisms of action are largely unknown. Similarly, the interaction between oxidative stress and altered dopaminergic activities in psychiatric… CONTINUE READING
    77 Citations
    Sex influences in the preventive effects of N-acetylcysteine in a two-hit animal model of schizophrenia
    • 2
    Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish
    • 8
    Putative neuroprotective agents in neuropsychiatric disorders
    • 85
    • PDF

    References

    SHOWING 1-10 OF 53 REFERENCES
    Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients
    • 302
    • PDF