N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.

  title={N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.},
  author={Ajay S. Unnithan and Yiran Jiang and Jennifer L Rumble and Sree H Pulugulla and Jessica M. Posimo and Amanda M. Gleixner and Rehana K Leak},
  journal={Neuroscience letters},
The two hit hypothesis of neurodegeneration states that cells that have been severely stressed once are more vulnerable to the negative impact of a second hit. In other words, the toxicity of two hits of severe stress may be synergistic in neurons. We previously developed a two hit model of proteotoxic neurodegeneration using the proteasome inhibitor MG132. In that study, we found that the potent antioxidant N-acetyl cysteine was able to protect against the toxicity associated with dual MG132… CONTINUE READING
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Leak , Nacetyl cysteine blunts proteotoxicity in a heat shock proteindependent manner

  • M. Patel, L. Calavetta, L. Y. Chang, J. S. Stamler
  • Neuroscience
  • 2013

The immunoproteasome , the 20 S proteasome and the PA 28 alphabeta proteasome regulator are oxidativestressadaptive proteolytic complexes

  • A. L. Koop, C. Y. Teoh, G. Ermak, T. Grune, K. J. Davies
  • Cell and Tissue Research
  • 2013

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