N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus.

@article{Petroff2003NacetylaspartateTC,
  title={N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus.},
  author={Ognen A. C. Petroff and Laura D. Errante and Jung Hwa Kim and Dennis D. Spencer},
  journal={Neurology},
  year={2003},
  volume={60 10},
  pages={1646-51}
}
BACKGROUND Mesial temporal lobe epilepsy (mTLE) is characterized by hippocampal atrophy, decreased N-acetyl-aspartate, and a low N-acetyl-aspartate/total creatine ratio, often attributed to neuron loss and gliosis. Qualitative studies reported that N-acetyl-aspartate content was significantly lower in hippocampal sclerosis. OBJECTIVE It was proposed to measure the effects of neuron loss and gliosis on the hippocampal content of N-acetyl-aspartate, total creatine, and myo-inositol in mTLE… CONTINUE READING